Ontology highlight
ABSTRACT:
SUBMITTER: Johnstone M
PROVIDER: S-EPMC4872463 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Johnstone Mandy M Maclean Alan A Heyrman Lien L Lenaerts An-Sofie AS Nordin Annelie A Nilsson Lars-Göran LG De Rijk Peter P Goossens Dirk D Adolfsson Rolf R St Clair David M DM Hall Jeremy J Lawrie Stephen M SM McIntosh Andrew M AM Del-Favero Jurgen J Blackwood Douglas H R DH Pickard Benjamin S BS
Molecular neuropsychiatry 20151007 3
Robust statistical, genetic and functional evidence supports a role for <i>DISC1</i> in the aetiology of major mental illness. Furthermore, many of its protein-binding partners show evidence for involvement in the pathophysiology of a range of neurodevelopmental and psychiatric disorders. Copy number variants (CNVs) are suspected to play an important causal role in these disorders. In this study, CNV analysis of <i>DISC1</i> and its binding partners <i>PAFAH1B1, NDE1, NDEL1, FEZ1, MAP1A, CIT</i> ...[more]