Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC4872596 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Yang Jing J Giles Logan J LJ Ruppelt Christian C Mendel Ralf R RR Bittner Florian F Kirk Martin L ML
Journal of the American Chemical Society 20150421 16
A combination of electron paramagnetic resonance (EPR) spectroscopy and computational approaches has provided insight into the nature of the reaction coordinate for the one-electron reduction of nitrite by the mitochondrial amidoxime reducing component (mARC) enzyme. The results show that a paramagnetic Mo(V) species is generated when reduced enzyme is exposed to nitrite, and an analysis of the resulting EPR hyperfine parameters confirms that mARC is remarkably similar to the low-pH form of sulf ...[more]