Ontology highlight
ABSTRACT:
SUBMITTER: Kannan A
PROVIDER: S-EPMC4872734 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Kannan Aarthi A Lin Zhenyu Z Shao Qiang Q Zhao Stephanie S Fang Bin B Moreno Mauricio A MA Vural Emre E Stack Brendan C BC Suen James Y JY Kannan Krishnaswamy K Gao Ling L
Oncotarget 20160201 6
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer. Pathologic activation of PI3K/mTOR pathway and elevated expression of c-Myc are frequently detected in MCC. Yet, there is no targeted therapy presently available for this lethal disease. Recently, MLN0128, a second-generation dual TORC1/2 inhibitor is shown to have therapeutic efficacy in preclinical studies. MLN0128 is currently in clinical trials as a potential therapy for advanced cancers. Here we characterize the therap ...[more]