The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse.
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ABSTRACT:
SUBMITTER: Riehl LM
PROVIDER: S-EPMC4872737 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse.
Riehl Lara M LM Schulte Johannes H JH Mulaw Medhanie A MA Dahlhaus Meike M Fischer Matthias M Schramm Alexander A Eggert Angelika A Debatin Klaus-Michael KM Beltinger Christian C
Oncotarget 20160201 6
Little is known about changes within the mitochondrial (mt) genome during tumor progression in general and during initiation and progression of neuroblastoma (NB) in particular. Whole exome sequencing of corresponding healthy tissue, primary tumor and relapsed tumor from 16 patients with NB revealed that most NB harbor tumor-specific mitochondrial variants. In relapsed tumors, the status of mt variants changed in parallel to the status of nuclear variants, as shown by increased number and spatio ...[more]
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