Ontology highlight
ABSTRACT:
SUBMITTER: Gruber W
PROVIDER: S-EPMC4872774 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Gruber Wolfgang W Hutzinger Martin M Elmer Dominik Patrick DP Parigger Thomas T Sternberg Christina C Cegielkowski Lukasz L Zaja Mirko M Leban Johann J Michel Susanne S Hamm Svetlana S Vitt Daniel D Aberger Fritz F
Oncotarget 20160201 6
A wide range of human malignancies displays aberrant activation of Hedgehog (HH)/GLI signaling, including cancers of the skin, brain, gastrointestinal tract and hematopoietic system. Targeting oncogenic HH/GLI signaling with small molecule inhibitors of the essential pathway effector Smoothened (SMO) has shown remarkable therapeutic effects in patients with advanced and metastatic basal cell carcinoma. However, acquired and de novo resistance to SMO inhibitors poses severe limitations to the use ...[more]