Dataset Information
A Fast Method for DEFB1 - 44C/G SNP Genotyping in Brazilian Patients with Periodontitis.
Ontology highlight
ABSTRACT: Aim
Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls.Material and methods
We used Hairpin-Shaped Primer (HP) assay to study the distribution of the -44 C/G SNP (rs1800972) in 119 human DNAs obtained from diabetic patients and healthy control patients.Results
The results indicate that there are no differences in distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently.Conclusion
Further studies are necessary in order to investigate the role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.
SUBMITTER: Cimoes R
PROVIDER: S-EPMC4872829 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
A Fast Method for DEFB1 - 44C/G SNP Genotyping in Brazilian Patients with Periodontitis.
Acta stomatologica Croatica 20140901 3
<h4>Aim</h4>Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls.<h4>Material and methods</h4>We used Hairpin-Shaped Primer (HP) assay to study the ...[more]
