Network Homeostasis and State Dynamics of Neocortical Sleep.
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ABSTRACT:
SUBMITTER: Watson BO
PROVIDER: S-EPMC4873379 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Network Homeostasis and State Dynamics of Neocortical Sleep.
Watson Brendon O BO Levenstein Daniel D Greene J Palmer JP Gelinas Jennifer N JN Buzsáki György G
Neuron 20160428 4
Sleep exerts many effects on mammalian forebrain networks, including homeostatic effects on both synaptic strengths and firing rates. We used large-scale recordings to examine the activity of neurons in the frontal cortex of rats and first observed that the distribution of pyramidal cell firing rates was wide and strongly skewed toward high firing rates. Moreover, neurons from different parts of that distribution were differentially modulated by sleep substates. Periods of nonREM sleep reduced t ...[more]
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