Ontology highlight
ABSTRACT:
SUBMITTER: Camp NJ
PROVIDER: S-EPMC4873429 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Camp Nicola J NJ Lin Wei-Yu WY Bigelow Alex A Burghel George J GJ Mosbruger Timothy L TL Parry Marina A MA Waller Rosalie G RG Rigas Sushilaben H SH Tai Pei-Yi PY Berrett Kristofer K Rajamanickam Venkatesh V Cosby Rachel R Brock Ian W IW Jones Brandt B Connley Dan D Sargent Robert R Wang Guoying G Factor Rachel E RE Bernard Philip S PS Cannon-Albright Lisa L Knight Stacey S Abo Ryan R Werner Theresa L TL Reed Malcolm W R MW Gertz Jason J Cox Angela A
Cancer research 20160121 7
The findings from genome-wide association studies hold enormous potential for novel insight into disease mechanisms. A major challenge in the field is to map these low-risk association signals to their underlying functional sequence variants (FSV). Simple sequence study designs are insufficient, as the vast numbers of statistically comparable variants and a limited knowledge of noncoding regulatory elements complicate prioritization. Furthermore, large sample sizes are typically required for ade ...[more]