Ontology highlight
ABSTRACT:
SUBMITTER: Svensson RJ
PROVIDER: S-EPMC4873565 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Svensson R J RJ Simonsson Ush U
CPT: pharmacometrics & systems pharmacology 20160517 5
This is the first clinical implementation of the Multistate Tuberculosis Pharmacometric (MTP) model describing fast-, slow-, and nonmultiplying bacterial states of Mycobacterium tuberculosis. Colony forming unit data from 19 patients treated with rifampicin were analyzed. A previously developed rifampicin population pharmacokinetic (PK) model was linked to the MTP model previously developed using in vitro data. Drug effect was implemented as exposure-response relationships tested at several effe ...[more]