Ontology highlight
ABSTRACT:
SUBMITTER: Fuste NP
PROVIDER: S-EPMC4873647 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Fusté Noel P NP Fernández-Hernández Rita R Cemeli Tània T Mirantes Cristina C Pedraza Neus N Rafel Marta M Torres-Rosell Jordi J Colomina Neus N Ferrezuelo Francisco F Dolcet Xavier X Garí Eloi E
Nature communications 20160516
Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1·Cdk4 expression promotes tumour growth and metastasis. While different nuclear Ccnd1·Cdk4 targets participating in cell proliferation and tissue development have been identified, little is known about how Ccnd1·Cdk4 controls cell adherence and invasion. Here, we show that the focal adhesion component paxillin is a cytoplasmic substrate of Ccn ...[more]