Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study.

ABSTRACT: Current evidence of proteinuria reduction as a surrogate target in advanced chronic kidney disease (CKD) is incomplete due to lack of patient-pooled database. We retrospectively studied a multicenter cohort of 1891 patients who were enrolled in the nationwide multidisciplinary pre-end stage renal disease care program with a baseline glomerular filtration rate (GFR) <45?mL/min/1.73?m(2) and followed longitudinally to investigate the effect of the change in proteinuria on renal death (defined as composite of dialysis and death occurring before initiation of dialysis). The group with a change in proteinuria ?0.30?g/g (n?=?1261) had lower cumulative probabilities of renal death (p?

SUBMITTER: Chen CH 

PROVIDER: S-EPMC4873744 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature