Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study.
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ABSTRACT:
SUBMITTER: Chen CH
PROVIDER: S-EPMC4873744 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
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Proteinuria as a Therapeutic Target in Advanced Chronic Kidney Disease: a Retrospective Multicenter Cohort Study.
Chen Chang-Hsu CH Wu Hon-Yen HY Wang Chieh-Li CL Yang Feng-Jung FJ Wu Pei-Chen PC Hung Szu-Chun SC Kan Wei-Chih WC Yang Chung-Wei CW Chiang Chih-Kang CK Huang Jenq-Wen JW Hung Kuan-Yu KY
Scientific reports 20160520
Current evidence of proteinuria reduction as a surrogate target in advanced chronic kidney disease (CKD) is incomplete due to lack of patient-pooled database. We retrospectively studied a multicenter cohort of 1891 patients who were enrolled in the nationwide multidisciplinary pre-end stage renal disease care program with a baseline glomerular filtration rate (GFR) <45 mL/min/1.73 m(2) and followed longitudinally to investigate the effect of the change in proteinuria on renal death (defined as c ...[more]
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