Ontology highlight
ABSTRACT:
SUBMITTER: Chang HH
PROVIDER: S-EPMC4873826 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Chang Hsiao-Han HH Meibalan Elamaran E Zelin Justin J Daniels Rachel R Eziefula Alice C AC Meyer Evan C EC Tadesse Fitsum F Grignard Lynn L Joice Regina C RC Drakeley Chris C Wirth Dyann F DF Volkman Sarah K SK Buckee Caroline C Bousema Teun T Marti Matthias M
Scientific reports 20160520
Artemisinin resistance is rapidly spreading in Southeast Asia. The efficacy of artemisinin-combination therapy (ACT) continues to be excellent across Africa. We performed parasite transcriptional profiling and genotyping on samples from an antimalarial treatment trial in Uganda. We used qRT-PCR and genotyping to characterize residual circulating parasite populations after treatment with either ACT or ACT-primaquine. Transcripts suggestive of circulating ring stage parasites were present after tr ...[more]