Ontology highlight
ABSTRACT:
SUBMITTER: Vedagiri D
PROVIDER: S-EPMC4873837 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Vedagiri Dhiviya D Lashkari Hiren Vasantrai HV Mangani Abubakar Siddiq AS Kumar Jerald Mahesh JM Jose Jedy J Thatipalli Avinash Raj AR Harshan Krishnan Harinivas KH
Scientific reports 20160520
Intrahepatic and extrahepatic metastases are frequently detected in hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is believed to drive metastasis. There are not many well-established model systems to study EMT in HCC. Here we identified an atypical EMT while characterizing a population of mesenchymal cells in Huh7.5 hepatoma cell cultures. Cells with distinct morphology appeared during geneticin treatment of Huh7.5 cultures. Molecular characterization of geneticin resis ...[more]