Ontology highlight
ABSTRACT:
SUBMITTER: Pennington LF
PROVIDER: S-EPMC4873975 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Nature communications 20160519
Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab-Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-affinity IgE receptors, and explains why omalizumab selectively binds free IgE. The structure of the complex also provides mechanistic insight into a class of disruptive IgE inhibitors that accelerate the dissociation of the high-a ...[more]