Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4874033 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Zhang Yumiao Y Song Wentao W Geng Jumin J Chitgupi Upendra U Unsal Hande H Federizon Jasmin J Rzayev Javid J Sukumaran Dinesh K DK Alexandridis Paschalis P Lovell Jonathan F JF
Nature communications 20160519
Injectable hydrophobic drugs are typically dissolved in surfactants and non-aqueous solvents which can induce negative side-effects. Alternatives like 'top-down' fine milling of excipient-free injectable drug suspensions are not yet clinically viable and 'bottom-up' self-assembled delivery systems usually substitute one solubilizing excipient for another, bringing new issues to consider. Here, we show that Pluronic (Poloxamer) block copolymers are amenable to low-temperature processing to strip ...[more]