Joint estimation of chemical shift and quantitative susceptibility mapping (chemical QSM).

ABSTRACT:

Purpose

The purpose of this work is to address the unsolved problem of quantitative susceptibility mapping (QSM) of tissue with fat where both fat and susceptibility change the MR signal phase.

Theory and methods

The chemical shift of fat was treated as an additional unknown and was estimated jointly with susceptibility to provide the best data fitting using an automated and iterative algorithm. A simplified susceptibility model was used to calculate an updated value of the chemical shift based on the local magnetic field in each iteration. Numerical simulation, phantom experiments and in vivo imaging were performed. Artifacts were assessed by measuring the susceptibility variance in uniform regions. Accuracy was assessed by comparison with ground truth in simulation, and us

SUBMITTER: Dimov AV 

PROVIDER: S-EPMC4874185 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature