Ontology highlight
ABSTRACT:
SUBMITTER: Zahn R
PROVIDER: S-EPMC4874776 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Zahn Raphael R Osmanović Dino D Ehret Severin S Araya Callis Carolina C Frey Steffen S Stewart Murray M You Changjiang C Görlich Dirk D Hoogenboom Bart W BW Richter Ralf P RP
eLife 20160408
The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytoplasmic exchange. It consists of nucleoporin domains rich in phenylalanine-glycine motifs (FG domains). As a bottom-up nanoscale model for the permeability barrier, we have used planar films produced with three different end-grafted FG domains, and quantitatively analyzed the binding of two different nuclear transport receptors (NTRs), NTF2 and Importin β, together with the concomitant film thickness changes. NTR b ...[more]