Ontology highlight
ABSTRACT:
SUBMITTER: Lemieux B
PROVIDER: S-EPMC4874874 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Lemieux Bruno B Laterreur Nancy N Perederina Anna A Noël Jean-François JF Dubois Marie-Line ML Krasilnikov Andrey S AS Wellinger Raymund J RJ
Cell 20160505 5
Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme. Pop1/Pop6/Pop7 binding is specific and involves an RNA ...[more]