Ontology highlight
ABSTRACT:
SUBMITTER: Um C
PROVIDER: S-EPMC4874882 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Organic letters 20160510 10
2-Arylpyrrolidines occur frequently in bioactive compounds, and thus, methods to access them from readily available reagents are valuable. We report a copper-catalyzed intermolecular carboamination of vinylarenes with potassium N-carbamoyl-β-aminoethyltrifluoroborates. The reaction occurs with terminal, 1,2-disubstituted, and 1,1-disubstituted vinylarenes bearing a number of functional groups. 1,3-Dienes are also good substrates, and their reactions give 2-vinylpyrrolidines. Radical clock mechan ...[more]