Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature.
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ABSTRACT:
SUBMITTER: Zhou Q
PROVIDER: S-EPMC4875242 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature.
Zhou Qiangjun Q Zhai Yujia Y Lou Jizhong J Liu Man M Pang Xiaoyun X Sun Fei F
Protein & cell 20110701 7
The mitochondrial respiratory complex II or succinate: ubiquinone oxidoreductase (SQR) is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration. Five disinfectant compounds were investigated with their potent inhibition effects on the ubiquinone reduction activity of the porcine mitochondrial SQR by enzymatic assay and crystallography. Crystal structure of the SQR bound with thiabendazole (TBZ) reveals a different inhibitor-binding feature at the ubiquinone binding ...[more]
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