Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC4875550 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Liu Zhigang Z Wu Shu-Wen SW Lei Cao-Qi CQ Zhou Qian Q Li Shu S Shu Hong-Bing HB Wang Yan-Yi YY
Protein & cell 20130430 5
In response to viral infection, RIG-I-like RNA helicases detect viral RNA and signal through the mitochondrial adapter protein VISA. VISA activation leads to rapid activation of transcription factors IRF3 and NF-κB, which collaborate to induce transcription of type I interferon (IFN) genes and cellular antiviral response. It has been demonstrated that VISA is activated by forming prion-like aggregates. However, how this process is regulated remains unknown. Here we show that overexpression of HS ...[more]