Ontology highlight
ABSTRACT:
SUBMITTER: Seigel GM
PROVIDER: S-EPMC4875886 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Seigel G M GM Sharma S S Hackam A S AS Shah Dhaval K DK
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20151127 5
Retinoblastoma (RB) is an ocular malignancy of early childhood. Although mutations in the Rb1 gene and expression of stem cell markers have been identified in RB, additional information on RB-specific alterations in signaling pathways and protein expression would be useful for the design of targeted RB therapies. Here we have evaluated the expression of HER2 (ERBB2) in RB. HER2 is a member of the epidermal growth factor family, which is overexpressed in breast, ovarian, gastric, colorectal, panc ...[more]