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The role of microglia and macrophages in glioma maintenance and progression.

ABSTRACT: There is a growing recognition that gliomas are complex tumors composed of neoplastic and non-neoplastic cells, which each individually contribute to cancer formation, progression and response to treatment. The majority of the non-neoplastic cells are tumor-associated macrophages (TAMs), either of peripheral origin or representing brain-intrinsic microglia, that create a supportive stroma for neoplastic cell expansion and invasion. TAMs are recruited to the glioma environment, have immune functions, and can release a wide array of growth factors and cytokines in response to those factors produced by cancer cells. In this manner, TAMs facilitate tumor proliferation, survival and migration. Through such iterative interactions, a unique tumor ecosystem is established, which offers new opportunities for therapeutic targeting.

SUBMITTER: Hambardzumyan D

PROVIDER: S-EPMC4876023 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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The role of microglia and macrophages in glioma maintenance and progression.

Hambardzumyan Dolores D Gutmann David H DH Kettenmann Helmut H

Nature neuroscience 20160101 1

There is a growing recognition that gliomas are complex tumors composed of neoplastic and non-neoplastic cells, which each individually contribute to cancer formation, progression and response to treatment. The majority of the non-neoplastic cells are tumor-associated macrophages (TAMs), either of peripheral origin or representing brain-intrinsic microglia, that create a supportive stroma for neoplastic cell expansion and invasion. TAMs are recruited to the glioma environment, have immune functi ...[more]

PMID: 26713745

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