Ontology highlight
ABSTRACT:
SUBMITTER: Hillmen P
PROVIDER: S-EPMC4876343 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Hillmen Peter P Gribben John G JG Follows George A GA Milligan Donald D Sayala Hazem A HA Moreton Paul P Oscier David G DG Dearden Claire E CE Kennedy Daniel B DB Pettitt Andrew R AR Nathwani Amit A Varghese Abraham A Cohen Dena D Rawstron Andy A Oertel Stephan S Pocock Christopher F E CF
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20140317 12
<h4>Purpose</h4>Most patients with chronic lymphocytic leukemia (CLL) are elderly and/or have comorbidities that may make them ineligible for fludarabine-based treatment. For this population, chlorambucil monotherapy is an appropriate therapeutic option; however, response rates with chlorambucil are low, and more effective treatments are needed. This trial was designed to assess how the addition of rituximab to chlorambucil (R-chlorambucil) would affect safety and efficacy in patients with CLL.< ...[more]