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Efficient one-pot synthesis of 1-arylcycloprop-2-ene-1-carboxamides.

ABSTRACT: An expeditious and cost-efficient method for synthesis of 1-arylcycloprop-2-ene-1-carboxamides was developed. This one-pot protocol involving coupling of amines with acyl chlorides, generated upon treatment of cyclopenylcarboxylic acids with oxalyl chloride, is applicable for the preparation of sensitive products with a reactive, unsubstituted strained double bond.

SUBMITTER: Edwards A

PROVIDER: S-EPMC4876632 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Efficient one-pot synthesis of 1-arylcycloprop-2-ene-1-carboxamides.

Edwards Andrew A Rubin Michael M

Organic & biomolecular chemistry 20160301 10

An expeditious and cost-efficient method for synthesis of 1-arylcycloprop-2-ene-1-carboxamides was developed. This one-pot protocol involving coupling of amines with acyl chlorides, generated upon treatment of cyclopenylcarboxylic acids with oxalyl chloride, is applicable for the preparation of sensitive products with a reactive, unsubstituted strained double bond. ...[more]

PMID: 26864495

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