Ontology highlight
ABSTRACT:
SUBMITTER: Muller MM
PROVIDER: S-EPMC4876634 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Müller Manuel M MM Fierz Beat B Bittova Lenka L Liszczak Glen G Muir Tom W TW
Nature chemical biology 20160125 3
Specialized chromatin domains contribute to nuclear organization and regulation of gene expression. Gene-poor regions are di- and trimethylated at lysine 9 of histone H3 (H3K9me2 and H3K9me3) by the histone methyltransferase Suv39h1. This enzyme harnesses a positive feedback loop to spread H3K9me2 and H3K9me3 over extended heterochromatic regions. However, little is known about how feedback loops operate on complex biopolymers such as chromatin, in part because of the difficulty in obtaining sui ...[more]