Ontology highlight
ABSTRACT:
SUBMITTER: Haga CL
PROVIDER: S-EPMC4876818 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Haga Christopher L CL Velagapudi Sai Pradeep SP Strivelli Jacqueline R JR Yang Wang-Yong WY Disney Matthew D MD Phinney Donald G DG
ACS chemical biology 20150730 10
Hypoxia induces a complex circuit of gene expression that drives tumor progression and increases drug resistance. Defining these changes allows for an understanding of how hypoxia alters tumor biology and informs design of lead therapeutics. We probed the role of microRNA-544 (miR-544), which silences mammalian target of rapamycin (mTOR), in a hypoxic breast cancer model by using a small molecule (1) that selectively impedes the microRNA's biogenesis. Application of 1 to hypoxic tumor cells sele ...[more]