Poring over two-pore channel pore mutants.
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ABSTRACT:
SUBMITTER: Penny CJ
PROVIDER: S-EPMC4876920 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Poring over two-pore channel pore mutants.
Penny Christopher J CJ Patel Sandip S
Messenger (Los Angeles, Calif. : Print) 20150601 1
Two-pore channels are members of the voltage-gated ion channel superfamily. They localise to the endolysosomal system and are likely targets for the Ca<sup>2+</sup> mobilising messenger NAADP. In this brief review, we relate mutagenesis of the TPC pore to a recently published homology model and discuss how pore mutants are informing us of TPC function. Molecular physiology of these ubiquitous proteins is thus emerging. ...[more]
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