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Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.

ABSTRACT: Ten alkaloids (1-10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11-16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1-16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. Its activity was increased by more than fourfold as compared with parent compound 1.

SUBMITTER: Tan CJ

PROVIDER: S-EPMC4877041 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.

Tan Cheng-jian CJ Zhao Yu Y Goto Masuo M Hsieh Kan-Yen KY Yang Xiao-ming XM Morris-Natschke Susan L SL Liu Li-na LN Zhao Bao-yu BY Lee Kuo-Hsiung KH

Bioorganic & medicinal chemistry letters 20150905 5

Ten alkaloids (1-10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11-16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1-16, 20, 21) were evaluated for antiproliferative activity against five human tumor cell lines. Among them, the newly synthesized derivative 20 exhibited the best inhibitory activity against the tested cell lines. ...[more]

PMID: 26865176

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