Ontology highlight
ABSTRACT:
SUBMITTER: Stake M
PROVIDER: S-EPMC4877169 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Stake Matthew M Singh Deepali D Singh Gatikrushna G Marcela Hernandez J J Kaddis Maldonado Rebecca R Parent Leslie J LJ Boris-Lawrie Kathleen K
Virology 20151113
Essential host cofactors in retrovirus replication bind cis-acting sequences in the 5'untranslated region (UTR). Although host RBPs are crucial to all aspects of virus biology, elucidating their roles in replication remains a challenge to the field. Here RNA affinity-coupled-proteomics generated a comprehensive, unbiased inventory of human and avian RNA binding proteins (RBPs) co-isolating with 5'UTRs of HIV-1, spleen necrosis virus and Rous sarcoma virus. Applying stringent biochemical and stat ...[more]