Ontology highlight
ABSTRACT:
SUBMITTER: Moran CM
PROVIDER: S-EPMC4877186 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Moran Carlos M CM Salanga Matthew C MC Krieg Paul A PA
Developmental dynamics : an official publication of the American Association of Anatomists 20110307 6
Signaling by the hedgehog (Hh) family of secreted growth factors is essential for development of embryonic blood vessels. Embryos lacking Hh function have abundant endothelial cells but fail to assemble vascular cords or lumenized endothelial tubes. However, the role of Hh signaling during later aspects of vascular patterning and morphogenesis is largely unexplored. We have used small molecule inhibitors and agonists to alter activity of the Hh signaling pathway in the chick embryo. When cyclopa ...[more]