Atomic-level description of protein-lipid interactions using an accelerated membrane model.

ABSTRACT: Peripheral membrane proteins are structurally diverse proteins that are involved in fundamental cellular processes. Their activity of these proteins is frequently modulated through their interaction with cellular membranes, and as a result techniques to study the interfacial interaction between peripheral proteins and the membrane are in high demand. Due to the fluid nature of the membrane and the reversibility of protein-membrane interactions, the experimental study of these systems remains a challenging task. Molecular dynamics simulations offer a suitable approach to study protein-lipid interactions; however, the slow dynamics of the lipids often prevents sufficient sampling of specific membrane-protein interactions in atomistic simulations. To increase lipid dynamics while preserving t

SUBMITTER: Baylon JL 

PROVIDER: S-EPMC4877275 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature