Ontology highlight
ABSTRACT:
SUBMITTER: Moreno-Ortiz JM
PROVIDER: S-EPMC4877485 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Moreno-Ortiz Jose Miguel JM Ayala-Madrigal María de la Luz Mde L Corona-Rivera Jorge Román JR Centeno-Flores Manuel M Maciel-Gutiérrez Víctor V Franco-Topete Ramón Antonio RA Armendáriz-Borunda Juan J Hotchkiss Erin E Pérez-Carbonell Lucia L Rhees Jennifer J Boland Clement Richard CR Gutiérrez-Angulo Melva M
Gastroenterology research and practice 20160510
Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC) and extracolonic tumors. The aim of this study was to identify mutations in MMR genes in three Mexican patients with LS. Methods. Immunohistochemical analysis was performed as a prescreening method to identify absent protein expression. PCR, ...[more]