Ontology highlight
ABSTRACT:
SUBMITTER: Reim D
PROVIDER: S-EPMC4877498 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Reim Dominik D Weis Tobias M TM Halbedl Sonja S Delling Jan Philipp JP Grabrucker Andreas M AM Boeckers Tobias M TM Schmeisser Michael J MJ
Frontiers in Synaptic Neuroscience 20160524
The postsynaptic density or PSD is a submembranous compartment containing a wide array of proteins that contribute to both morphology and function of excitatory glutamatergic synapses. In this study, we have analyzed functional aspects of the Fezzin ProSAP-interacting protein 1 (ProSAPiP1), an interaction partner of the well-known PSD proteins Shank3 and SPAR. Using lentiviral-mediated overexpression and knockdown of ProSAPiP1, we found that this protein is dispensable for the formation of both ...[more]