Ontology highlight
ABSTRACT:
SUBMITTER: Pamula MC
PROVIDER: S-EPMC4878094 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Pamula Melissa C MC Ti Shih-Chieh SC Kapoor Tarun M TM
The Journal of cell biology 20160516 4
Diversity in cytoskeleton organization and function may be achieved through variations in primary sequence of tubulin isotypes. Recently, isotype functional diversity has been linked to a "tubulin code" in which the C-terminal tail, a region of substantial sequence divergence between isotypes, specifies interactions with microtubule-associated proteins. However, it is not known whether residue changes in this region alter microtubule dynamic instability. Here, we examine recombinant tubulin with ...[more]