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Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks.

ABSTRACT: In the nematode model organisms Caenorhabditis elegans and Pristionchus pacificus, a new class of natural products based on modular assembly of primary-metabolism-derived building blocks control organismal development and behavior. We report identification and biological activities of the first pentamodular metabolite, pasa#9, and the 8-oxoadenine-containing npar#3 from P. pacificus. These structures suggest co-option of nucleoside and tryptophan metabolic pathways for the biosynthesis of endogenous metabolite libraries that transcend the dichotomy between "primary" and "secondary" metabolism.

SUBMITTER: Yim JJ

PROVIDER: S-EPMC4878434 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks.

Yim Joshua J JJ Bose Neelanjan N Meyer Jan M JM Sommer Ralf J RJ Schroeder Frank C FC

Organic letters 20150318 7

In the nematode model organisms Caenorhabditis elegans and Pristionchus pacificus, a new class of natural products based on modular assembly of primary-metabolism-derived building blocks control organismal development and behavior. We report identification and biological activities of the first pentamodular metabolite, pasa#9, and the 8-oxoadenine-containing npar#3 from P. pacificus. These structures suggest co-option of nucleoside and tryptophan metabolic pathways for the biosynthesis of endoge ...[more]

PMID: 25782998

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