Ontology highlight
ABSTRACT:
SUBMITTER: Ju C
PROVIDER: S-EPMC4879168 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Journal of molecular medicine (Berlin, Germany) 20160420 6
Liver disease is a growing global health problem, as deaths from end-stage liver cirrhosis and cancer are rising across the world. At present, pharmacologic approaches to effectively treat or prevent liver disease are extremely limited. Hypoxia-inducible factor (HIF) is a transcription factor that regulates diverse signaling pathways enabling adaptive cellular responses to perturbations of the tissue microenvironment. HIF activation through hypoxia-dependent and hypoxia-independent signals have ...[more]