Ontology highlight
ABSTRACT:
SUBMITTER: Salaro E
PROVIDER: S-EPMC4879576 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Salaro Erica E Rambaldi Alessia A Falzoni Simonetta S Amoroso Francesca Saveria FS Franceschini Alessia A Sarti Alba Clara AC Bonora Massimo M Cavazzini Francesco F Rigolin Gian Matteo GM Ciccone Maria M Audrito Valentina V Deaglio Silvia S Pelegrin Pablo P Pinton Paolo P Cuneo Antonio A Di Virgilio Francesco F
Scientific reports 20160525
Lymphocyte growth and differentiation are modulated by extracellular nucleotides and P2 receptors. We previously showed that the P2X7 receptor (P2X7R or P2RX7) is overexpressed in circulating lymphocytes from chronic lymphocytic leukemia (CLL) patients. In the present study we investigated the P2X7R/NLRP3 inflammasome axis in lymphocytes from a cohort of 23 CLL patients. P2X7R, ASC and NLRP3 were investigated by Western blot, PCR and transfection techniques. P2X7R was overexpressed and correlate ...[more]