Dataset Information

Pharyngeal carriage of Neisseria species in the African meningitis belt.

ABSTRACT:

Objectives

Neisseria meningitidis, together with the non-pathogenic Neisseria species (NPNs), are members of the complex microbiota of the human pharynx. This paper investigates the influence of NPNs on the epidemiology of meningococcal infection.

Methods

Neisseria isolates were collected during 18 surveys conducted in six countries in the African meningitis belt between 2010 and 2012 and characterized at the rplF locus to determine species and at the variable region of the fetA antigen gene. Prevalence and risk factors for carriage were analyzed.

Results

A total of 4694 isolates of Neisseria were obtained from 46,034 pharyngeal swabs, a carriage prevalence of 10.2% (95% CI, 9.8-10.5). Five Neisseria species were identified, the most prevalent NPN being Neisseria lactamica. Six hundred and thirty-six combinations of rplF/fetA_VR alleles were identified, each defined as a Neisseria strain type. There was an inverse relationship between carriage of N. meningitidis and of NPNs by age group, gender and season, whereas carriage of both N. meningitidis and NPNs was negatively associated with a recent history of meningococcal vaccination.

Conclusion

Variations in the prevalence of NPNs by time, place and genetic type may contribute to the particular epidemiology of meningococcal disease in the African meningitis belt.

SUBMITTER: Diallo K

PROVIDER: S-EPMC4879866 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Publications

Pharyngeal carriage of Neisseria species in the African meningitis belt.

Diallo Kanny K Trotter Caroline C Timbine Youssouf Y Tamboura Boubou B Sow Samba O SO Issaka Bassira B Dano Ibrahim D ID Collard Jean-Marc JM Dieng Marietou M Diallo Aldiouma A Mihret Adane A Ali Oumer A OA Aseffa Abraham A Quaye Stephen L SL Bugri Akalifa A Osei Isaac I Gamougam Kadidja K Mbainadji Lodoum L Daugla Doumagoum M DM Gadzama Galadima G Sambo Zailani B ZB Omotara Babatunji A BA Bennett Julia S JS Rebbetts Lisa S LS Watkins Eleanor R ER Nascimento Maria M Woukeu Arouna A Manigart Olivier O Borrow Ray R Stuart James M JM Greenwood Brian M BM Maiden Martin C J MCJ

The Journal of infection 20160323 6

<h4>Objectives</h4>Neisseria meningitidis, together with the non-pathogenic Neisseria species (NPNs), are members of the complex microbiota of the human pharynx. This paper investigates the influence of NPNs on the epidemiology of meningococcal infection.<h4>Methods</h4>Neisseria isolates were collected during 18 surveys conducted in six countries in the African meningitis belt between 2010 and 2012 and characterized at the rplF locus to determine species and at the variable region of the fetA a ...[more]

PMID: 27018131

Similar Datasets

Project description:BackgroundTo facilitate the interpretation of meningococcal meningitis epidemiology in the "African meningitis belt", we aimed at obtaining serogroup-specific pooled estimates of incidence, carriage and case-carrier ratios for meningococcal meningitis in the African meningitis belt and describe their variations across the endemic, hyperendemic and epidemic context.MethodsWe conducted a systematic review and meta-analysis of studies reporting serogroup-specific meningococcal meningitis monthly incidence and carriage in the same population and time period. Epidemiological contexts were defined as endemic (wet season, no epidemic), hyperendemic (dry season, no epidemic), and epidemic (dry season, epidemic).FindingsEight studies reporting a total of eighty pairs of serogroup-specific meningococcal meningitis incidence and carriage estimates were included in this review. For serogroup A, changes associated with the transition from endemic to hyperendemic incidence and from hyperendemic to epidemic incidence were 15-fold and 120-fold respectively. Changes in carriage prevalence associated with both transitions were 1-fold and 30-fold respectively.  For serogroup W and X, the transition from endemic to hyperendemic incidence involved a 4-fold and 1•1-fold increase respectively. Increases in carriage prevalence for the later transition were 7-fold and 1•7-fold respectively. No data were available for the hyperendemic-epidemic transition for these serogroups. Our findings suggested that the regular seasonal variation in serogroup A meningococcal meningitis incidence between the rainy and the dry season could be mainly driven by seasonal change in the ratio of clinical cases to subclinical infections. In contrast appearance of epidemic incidences is related to a substantial increase in transmission and colonisation and to lesser extent with changes in the case-carrier ratio.ConclusionSeasonal change in the rate of progression to disease given carriage together with variations in frequency of carriage transmission should be considered in models attempting to capture the epidemiology of meningococcal meningitis and mainly to predict meningitis epidemics in the African meningitis belt.

Dataset Information

Pharyngeal carriage of Neisseria species in the African meningitis belt.

Objectives

Methods

Results

Conclusion

Publications

Pharyngeal carriage of Neisseria species in the African meningitis belt.

Similar Datasets

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