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A Versatile and Scalable Strategy to Discrete Oligomers.

ABSTRACT: A versatile strategy is reported for the multigram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, and siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multigram preparation of discrete oligomer libraries (? = 1.0). Synthetic availability, coupled with accurate structural control, allows these functional building blocks to be harnessed for both fundamental studies as well as targeted technological applications.

SUBMITTER: Lawrence J

PROVIDER: S-EPMC4879877 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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A Versatile and Scalable Strategy to Discrete Oligomers.

Lawrence Jimmy J Lee Sang-Ho SH Abdilla Allison A Nothling Mitchell D MD Ren Jing M JM Knight Abigail S AS Fleischmann Carolin C Li Youli Y Abrams Austin S AS Schmidt Bernhard V K J BV Hawker Michael C MC Connal Luke A LA McGrath Alaina J AJ Clark Paul G PG Gutekunst Will R WR Hawker Craig J CJ

Journal of the American Chemical Society 20160506 19

A versatile strategy is reported for the multigram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, and siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multigram preparation of discrete oligomer libraries (Đ = 1.0). Synthetic availability, coupled with acc ...[more]

PMID: 27152711

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