MicroRNA Species in Follicular Fluid Associating With Polycystic Ovary Syndrome and Related Intermediary Phenotypes.

ABSTRACT:

Context

Polycystic ovary syndrome (PCOS) has a largely unknown etiology and presents with a clinical heterogeneous patient group. Small noncoding microRNA (miRNA) might prove promising as biomarker candidates for PCOS patient stratification. Altered miRNA expression profiles have been observed in few studies.

Objective

The aim was to assess the miRNA expression profile in follicular fluid from PCOS patients and healthy, regularly cycling, matched controls.

Design and setting

Experimental case-control study including 49 PCOS women (19 of which were hyperandrogenic and 30 normo-androgenic) and 21 healthy matched women all undergoing in vitro fertilization treatment.

Interventions and main outcome

Anthropometric and relevant clinical baseline measurements were obt

SUBMITTER: Sorensen AE 

PROVIDER: S-EPMC4880172 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature