Ontology highlight
ABSTRACT:
SUBMITTER: Gacias M
PROVIDER: S-EPMC4880443 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Gacias Mar M Gaspari Sevasti S Santos Patricia-Mae G PM Tamburini Sabrina S Andrade Monica M Zhang Fan F Shen Nan N Tolstikov Vladimir V Kiebish Michael A MA Dupree Jeffrey L JL Zachariou Venetia V Clemente Jose C JC Casaccia Patrizia P
eLife 20160420
Gene-environment interactions impact the development of neuropsychiatric disorders, but the relative contributions are unclear. Here, we identify gut microbiota as sufficient to induce depressive-like behaviors in genetically distinct mouse strains. Daily gavage of vehicle (dH2O) in nonobese diabetic (NOD) mice induced a social avoidance behavior that was not observed in C57BL/6 mice. This was not observed in NOD animals with depleted microbiota via oral administration of antibiotics. Transfer o ...[more]