Cessation of alcohol consumption decreases rate of nicotine metabolism in male alcohol-dependent smokers.

ABSTRACT:

Background

Rate of nicotine metabolism is an important factor influencing cigarette smoking behavior, dependence, and efficacy of nicotine replacement therapy. The current study examined the hypothesis that chronic alcohol abuse can accelerate the rate of nicotine metabolism. Nicotine metabolite ratio (NMR, a biomarker for rate of nicotine metabolism) and patterns of nicotine metabolites were assessed at three time points after alcohol cessation.

Methods

Participants were 22 Caucasian men randomly selected from a sample of 165 smokers entering a 7-week alcohol dependence treatment program in Poland. Data were collected at three time points: baseline (week 1, after acute alcohol detoxification), week 4, and week 7. Urine was analyzed for nicotine and metabolites and used to d

SUBMITTER: Gubner NR 

PROVIDER: S-EPMC4880506 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature