Ontology highlight
ABSTRACT:
SUBMITTER: Wheeler SR
PROVIDER: S-EPMC4880766 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Wheeler Scott R SR Shi Chanjuan C Holt Jonathan A JA Vnencak-Jones Cindy L CL
Journal of gastrointestinal oncology 20160601 3
Patients with Lynch syndrome often present with multiple synchronous or metachronous colorectal cancers (CRCs). The presence of multiple CRCs with distinct genetic profiles and driver mutations could complicate treatment as each cancer may respond differently to therapy. Studies of sporadic CRCs suggested that synchronous tumors have distinct etiologies, but could not rule out differences in genetic background. The presence of multiple cancers in a patient with a predisposing mutation provides a ...[more]