Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Manzo S
PROVIDER: S-EPMC4881603 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Gómez-Manzo Saúl S Marcial-Quino Jaime J Vanoye-Carlo America A Serrano-Posada Hugo H González-Valdez Abigail A Martínez-Rosas Víctor V Hernández-Ochoa Beatriz B Sierra-Palacios Edgar E Castillo-Rodríguez Rosa Angélica RA Cuevas-Cruz Miguel M Rodríguez-Bustamante Eduardo E Arreguin-Espinosa Roberto R
International journal of molecular sciences 20160521 5
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. In order to understand the effect of the mutations in G6PD gene function and its relation with G6PD deficiency severity, we report the construction, cloning and expression as well as the detailed kinetic and stability characterization of three purified clinical ...[more]