Ontology highlight
ABSTRACT:
SUBMITTER: Mamaeva V
PROVIDER: S-EPMC4881775 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20160226 5
Cancer stem cells (CSCs) are a challenge in cancer treatment due to their therapy resistance. We demonstrated that enhanced Notch signaling in breast cancer promotes self-renewal of CSCs that display high glycolytic activity and aggressive hormone-independent tumor growth in vivo. We took advantage of the glycolytic phenotype and the dependence on Notch activity of the CSCs and designed nanoparticles to target the CSCs. Mesoporous silica nanoparticles were functionalized with glucose moieties an ...[more]