Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.
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ABSTRACT:
SUBMITTER: Krishn SR
PROVIDER: S-EPMC4881851 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer.
Krishn Shiv Ram SR Kaur Sukhwinder S Smith Lynette M LM Johansson Sonny L SL Jain Maneesh M Patel Asish A Gautam Shailendra K SK Hollingsworth Michael A MA Mandel Ulla U Clausen Henrik H Lo Wing-Cheong WC Fan Wai-Tong Louis WT Manne Upender U Batra Surinder K SK
Cancer letters 20160216 2
Development of biomarkers that detect early stage resectable premalignant lesions of colon can provide critical aid in the prevention of colorectal cancer. Recent lines of evidence suggest the utility of mucin expression to predict malignant transformation of colon pre-neoplastic lesions. In this study, we investigated the combined expression of multiple mucins and mucin-associated glycans during the adenoma-carcinoma sequence of colon cancer progression. Further, we evaluated their applicabilit ...[more]
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