Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study.
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ABSTRACT: Background
A role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited.Methods
A total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C. trachomatis and HPV DNA by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay.Results
Only 1.7% of samples were positive for C. trachomatis, with no significant differences between AC/AIS cases and controls. HPV-positivity was detected in 49.3% of C. trachomatis-negative and 65.4% C. trachomatis-positive samples, respectively.Conclusions
A large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C. trachomatis infection.Impact
C. trachomatis appears not to be involved in cervical adenocarcinomas.
SUBMITTER: Smelov V
PROVIDER: S-EPMC4881944 | biostudies-literature |
REPOSITORIES: biostudies-literature
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