Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC4882190 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Cell 20160201 4
While alternative splicing is known to diversify the functional characteristics of some genes, the extent to which protein isoforms globally contribute to functional complexity on a proteomic scale remains unknown. To address this systematically, we cloned full-length open reading frames of alternatively spliced transcripts for a large number of human genes and used protein-protein interaction profiling to functionally compare hundreds of protein isoform pairs. The majority of isoform pairs shar ...[more]