Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
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ABSTRACT:
SUBMITTER: Ueno M
PROVIDER: S-EPMC4882232 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
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Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
Ueno Masaki M Ueno-Nakamura Yuka Y Niehaus Jesse J Popovich Phillip G PG Yoshida Yutaka Y
Nature neuroscience 20160418 6
Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating co ...[more]
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